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How does the #brain maintain stable sound representations sound despite variable background noise? This study by Omedas & Williamson identifies a functional division across #auditory cortex layers, linking noise-invariance to deep-layer pathways.

plos.io/45a1TRI

Two-photon recordings from awake, head-fixed mice. (Top) Schematic of acoustic stimulation in the absence (No-BN) and presence (BN) of continuous background noise. (Lower left) Examples of the appearance during imaging from each recorded subpopulation. L2/3 were the most superficial, while L5 ET were the deepest. (Lower right) Example sound-evoked calcium responses and corresponding z-scored deconvolved spikes at the best frequency for one representative neuron from each field of view shown to the left. The effect of background noise was much larger for the superficial L2/3 neurons than for the other populations.
#brain #auditory
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