Manually managing the domains you block is absolutely no substitute for actually good moderation tools, where #Mastodon has a lot of work to do.
But in the meantime, if your instance doesn't have a good blocklist, you can upload this CSV to your "Domain blocking list" at example.social/settings/imports to block some of the worst instances:
blocklists/blocklists/mastodon/_unified_tier0_blocklist.csv at main
blocklists - BlocklistsCodeberg.org
