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There is no sign of #SarsCoV2 mutation rate slowing down.

The march upwards in Immune Escape & ACE2 binding strength continues.

There is no sign #SARS2 is running out of evolutionary space.

🧵@TRyanGregory
https://threadreaderapp.com/thread/1801997622376354200.html

#SARS2 #COVID19 #CovidIsNotOver #ForeverCovid

A plot of mutations over time of SARS2. It is linearly increasing with a rate estimate of 29.7 substitutions per year.
Immune escape plot of SARS vs BA.2 over time. intercept = -1.25e3 slope=0.619 R^2 = 0.765

Thread by @TRyanGregory on Thread Reader App

@TRyanGregory: Is SARS-CoV-2 running out of evolutionary space? Is variant evolution slowing down? Is immune escape unlikely anymore? Let's explore. 🧵 Here are some phylogenies (evolutionary trees) of the major SARS...…
threadreaderapp.com
#COVID19 #sarscov2 #CovidIsNotOver #SARS2 #forevercovid @T. Ryan Gregory

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